How We Can Support the Drug Development Pipeline

Histopathology and Path Review

 Histopathology is a major bottleneck for drug development studies. Source BioScience has a fully equipped histology laboratory to provide a range of histology services to support clinical and R & D studies. We apply rigorous quality control procedures and comply with national and international guidelines. Our laboratory is CPA,GLP and GCP accredited and participates in NEQAS Schemes.

We can accept a range of samples including wet specimens, paraffin blocks or pre-prepared slides. All samples are organised and accurately logged and tracked by trained professionals, ensuring integrity of the process.

Our services include:

• Provision of formalin fixative pots to clinical sites/labs to fix tissue biopsies/samples.
• Processing of tissue to block including orientation of tissue to meet study requirements.
• Sectioning including specialist cutting of delicate tissues such as brain and heart.
• Standard H & E.
• Specialist staining to look at tissue structure in detail.
• quantitative IHC/FISH including assay development, validation and ploidy assessment to aid development of new therapeutics.
• Diagnostic tests to aid pathology diagnosis including HER2; EGFR;ER;PR;KRAS;BRAF (for further information please see mutation analysis and biomarker analysis).
• By eye or automated image analysis and telepathology allowing images to be viewed over a secure web browser.
• Expert pathology review supported by a team of 65 pathologists and Vets.
• Source BioScience supports clinical trial and research studies globally, providing formalin pot site kits and manuals, as required.
• Features such as size of tumour, grade and stage of cancer including any lymph node spread can also be ascertained.

Blocks/samples can be stored for clinical trials and research studies if required. Please note that genomic extraction and rescue of genomic material from archived blocks is another service that we offer.

For further information please contact us at: pharma