How We Can Support the Drug Development Pipeline

Next Generation Sequencing Using The Illumina Genome Analyzer and its Applications

Description

As a leading provider of genomic services in the UK, and a preferred UK supplier of Illumina services, Source BioScience is pleased to offer the Illumina Genome Analyzer technology to support drug development and clinical research programs.

Genome Analyzer Technology

Based on revolutionary Solexa® Sequencing technology, the Illumina Genome Analysis system is a groundbreaking new platform for genetic analysis and functional genomics. It dramatically improves speed and reduces costs, completing projects in days rather than weeks, shortening drug development program times significantly. Leveraging proprietary reversible terminators and Clonal Single Molecule Array technology, the Illumina Genome Analysis system has the potential to generate upwards of one to three billion bases of data per run, and in the process transform the way many experiments are devised and carried out.

Applications of Genome Analyzer

Genome Sequencing and Resequencing:

• Discover and confirm SNPs which may affect patient response to treatment
• Identify chromosomal rearrangements, including Copy Number Variations (CNVs)
• Map break points
• Detect rare variants which may affect drug safety profiles

Digital Gene Expression

Generates genome-wide expression profiles through sequencing and not hybridization shortening profiling times and increasing sensitivity. Illumina offers two Digital Gene Expression applications:

Tag Profiling

• Tag Profiling produces high-quality quantitative data empowering whole-genome profiling of any polyadenylated mRNA.
• Sequence knowledge not required - universal platform to study any transcript

For further information on Illumina Goldengate and Infinium sequencing, please click here.

Contact enquiries at: +44 (0)115 973 9012 Or
Email us at: pharma